Regulation of type I collagen genes expression
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چکیده
منابع مشابه
Regulation of type I collagen genes expression.
Type I collagen, the most abundant protein of the body, is preferentially synthesized in bone, dermis, and tendons by two cell types, the osteoblast and the fibroblast. The expression of type I collagen is increased in the various forms of fibrosis such as lung, liver, bone marrow fibrosis and scleroderma. Type I collagen is a heterotrimer molecule consisting of two alpha 1(I) chains and one al...
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Type I collagen is the most abundant structural protein in all vertebrates, but its constitutive rate of synthesis is low due to long half-life of the protein (60-70 days). However, several hundred fold increased production of type I collagen is often seen in reparative or reactive fibrosis. The mechanism which is responsible for this dramatic upregulation is complex, including multiple levels ...
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Collagen gene expression during mouse molar tooth development was studied by quantitative in situ hybridization techniques. Different expression patterns of type I and type III collagen mRNAs were observed in the various mesenchymal tissues that constitute the tooth germ. High concentration for pro-alpha 1(I) and pro-alpha 2(I) collagen mRNAs were found within the osteoblasts. We found that the...
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Fibrosis is a hallmark symptom in a number of human diseases, including scleroderma, lung fibrosis, liver cirrhosis, atherosclerosis, osteoarthritis, and keloids. The most prominent biochemical manifestation of fibrotic lesions is an abnormal accumulation of extracellular matrix components, including type I and III collagen in mesenchymal tissues. This abnormal accumulation often results in sev...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2000
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/15.suppl_6.66